Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance.

He, Yunhua; Wang, Yuchan; Liu, Hong; Xu, Xiaohong; He, Song; Tang, Jie; Huang, Yuejiao; Miao, Xiaobing; Wu, Yaxun; Wang, Qiru; Cheng, Chun

He, Yunhua; Wang, Yuchan; Liu, Hong; Xu, Xiaohong; He, Song; Tang, Jie; Huang, Yuejiao; Miao, Xiaobing; Wu, Yaxun; Wang, Qiru; Cheng, Chun.

Afiliação

He Y; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College, Nantong University, Nantong 226001, Jiangsu Province, People's Republic of China.
Wang Y; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College, Nantong University, Nantong 226001, Jiangsu Province, People's Republic of China.
Liu H; Department of Hematology, Affiliated Hospital of Nantong University, Nantong University, Nantong 22600, Jiangsu Province, People's Republic of China.
Xu X; Department of Oncology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
He S; Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
Tang J; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College, Nantong University, Nantong 226001, Jiangsu Province, People's Republic of China.
Huang Y; Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
Miao X; Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
Wu Y; Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
Wang Q; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College, Nantong University, Nantong 226001, Jiangsu Province, People's Republic of China.
Cheng C; Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College, Nantong University, Nantong 226001, Jiangsu Province, People's Republic of China. Electronic address: ntchengchun@sina.com.

Leuk Res ; 39(12): 1428-36, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26453405

Assuntos

Proteínas de Transporte/fisiologia; Proteínas de Membrana/fisiologia; Mieloma Múltiplo/enzimologia; Proteínas de Neoplasias/fisiologia; Hormônios Tireóideos/fisiologia; Proteínas de Transporte/biossíntese; Proteínas de Transporte/genética; Adesão Celular; Divisão Celular; Linhagem Celular Tumoral; Técnicas de Cocultura; Inibidor de Quinase Dependente de Ciclina p27/biossíntese; Inibidor de Quinase Dependente de Ciclina p27/genética; Resistencia a Medicamentos Antineoplásicos; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Fibronectinas; Regulação Neoplásica da Expressão Gênica; Humanos; Proteínas de Membrana/biossíntese; Proteínas de Membrana/genética; Mieloma Múltiplo/patologia; Proteínas de Neoplasias/biossíntese; Proteínas de Neoplasias/genética; Fenótipo; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação; Processamento de Proteína Pós-Traducional; Proteínas Proto-Oncogênicas c-akt/metabolismo; Interferência de RNA; RNA Interferente Pequeno/genética; Transdução de Sinais/fisiologia; Células Estromais; Hormônios Tireóideos/biossíntese; Hormônios Tireóideos/genética; Proteínas de Ligação a Hormônio da Tireoide

Palavras-chave

CAM-DR; MAPK/ERK; MM; PI3K/Akt; PKM2; Proliferation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Tireóideos / Proteínas de Transporte / Proteínas de Membrana / Mieloma Múltiplo / Proteínas de Neoplasias Limite: Humans Idioma: En Revista: Leuk Res Ano de publicação: 2015 Tipo de documento: Article

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