The voltage-gated sodium channel NaV 1.9 in visceral pain.
Neurogastroenterol Motil
; 28(3): 316-26, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26462871
ABSTRACT
BACKGROUND:
Visceral pain is a common symptom for patients with gastrointestinal (GI) disease. It is unpleasant, debilitating, and represents a large unmet medical need for effective clinical treatments. Recent studies have identified NaV 1.9 as an important regulator of afferent sensitivity in visceral pain pathways to mechanical and inflammatory stimuli, suggesting that NaV 1.9 could represent an important therapeutic target for the treatment of visceral pain. This potential has been highlighted by the identification of patients who have an insensitivity to pain or painful neuropathies associated with mutations in SCN11A, the gene encoding voltage-gated sodium channel subtype 1.9 (NaV 1.9).PURPOSE:
Here, we address the role of NaV 1.9 in visceral pain and what known human NaV 1.9 mutants can tell us about NaV 1.9 function in gut physiology and pathophysiology.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Visceral
/
Canal de Sódio Disparado por Voltagem NAV1.9
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurogastroenterol Motil
Ano de publicação:
2016
Tipo de documento:
Article