Your browser doesn't support javascript.

Biblioteca Virtual em Saúde

Brasil

Home > Pesquisa > ()
Imprimir Exportar

Formato de exportação:

Exportar

Email
Adicionar mais destinatários
| |

Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes.

Simmons, James A; D'Souza, Ryan S; Ruas, Margarida; Galione, Antony; Casanova, James E; White, Judith M.
J Virol; 90(1): 605-10, 2016 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-26468524
Ebolavirus, a deadly hemorrhagic fever virus, was thought to enter cells through endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an alternate model was recently proposed in which ebolavirus enters through a later NPC1-negative endosome that contains two-pore Ca(2+) channel 2 (TPC2), a newly identified ebolavirus entry factor. Here, using live cell imaging, we obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 and TPC2.
Selo DaSilva