Spherical nanoparticle supported lipid bilayers for the structural study of membrane geometry-sensitive molecules.
J Am Chem Soc
; 137(44): 14031-14034, 2015 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-26488086
ABSTRACT
Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Membrana Celular
/
Nanopartículas
/
Bicamadas Lipídicas
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2015
Tipo de documento:
Article