Frontotemporal Dysfunction and Dementia in Amyotrophic Lateral Sclerosis.
Neurol Clin
; 33(4): 787-805, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26515622
ABSTRACT
Although amyotrophic lateral sclerosis (ALS) is classically considered a disorder exclusively affecting motor neurons, there is substantial clinical, neuroimaging, and neuropathologic evidence that more than half of patients have an associated syndrome of frontotemporal dysfunction. These syndromes range from frontotemporal dementia to behavioral or cognitive syndromes. Neuroimaging and neuropathologic findings are consistent with frontotemporal lobar degeneration that underpins alterations in network connectivity. Future clinical trials need to be stratified based on the presence or absence of frontotemporal dysfunction on the disease course of ALS.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Degeneração Lobar Frontotemporal
/
Demência Frontotemporal
/
Esclerose Lateral Amiotrófica
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurol Clin
Ano de publicação:
2015
Tipo de documento:
Article