D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts.

Iannuzzi, Clara; Borriello, Margherita; Carafa, Vincenzo; Altucci, Lucia; Vitiello, Milena; Balestrieri, Maria Luisa; Ricci, Giulia; Irace, Gaetano; Sirangelo, Ivana

Iannuzzi, Clara; Borriello, Margherita; Carafa, Vincenzo; Altucci, Lucia; Vitiello, Milena; Balestrieri, Maria Luisa; Ricci, Giulia; Irace, Gaetano; Sirangelo, Ivana.

Afiliação

Iannuzzi C; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Borriello M; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Carafa V; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Altucci L; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Naples, Italy.
Vitiello M; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Balestrieri ML; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Ricci G; Department of Experimental Medicine, Second University of Naples, Naples, Italy.
Irace G; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
Sirangelo I; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy. Electronic address: ivana.sirangelo@unina2.it.

Biochim Biophys Acta ; 1862(1): 93-104, 2016 01.

Article em En | MEDLINE | ID: mdl-26519138

Assuntos

Amiloide/metabolismo; Apoptose; Insulina/metabolismo; Agregação Patológica de Proteínas/metabolismo; Ribose/metabolismo; Amiloide/química; Amiloide/ultraestrutura; Animais; Sobrevivência Celular; Glicosilação; Humanos; Insulina/química; Camundongos; NF-kappa B/metabolismo; Células NIH 3T3; Conformação Proteica; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Amyloid aggregation; Apoptosis; D-ribose; Insulin glycation; NF-kB; ROS production

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribose / Apoptose / Agregação Patológica de Proteínas / Amiloide / Insulina Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article

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