[At the border of pluri- and multipotency: the neural crest stem cells]. / A pluri- és multipotencia határán: a ganglionléc ossejtjei.
Orv Hetil
; 156(42): 1683-94, 2015 Oct 18.
Article
em Hu
| MEDLINE
| ID: mdl-26551308
ABSTRACT
The neural crest is a transient, multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the neuronal and glial components of the peripheral nervous system to the ectomesenchymal derivatives of the craniofacial area and pigment cells in the skin. Intriguingly, the neural crest derived stem cells are not only present in the embryonic neural crest, but also in their target tissues in the fetus and adult. These postmigratory stem cells, at least partially, resemble their multipotency. Moreover, fully differentiated neural crest-derived cells such as Schwann cells and melanocytes are able to dedifferentiate into stem-like progenitors. Here the authors review current understanding of this unique plasticity and its potential application in stem cell biology as well as in regenerative medicine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Células-Tronco Multipotentes
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Células-Tronco Pluripotentes
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Desdiferenciação Celular
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Crista Neural
Limite:
Animals
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Humans
Idioma:
Hu
Revista:
Orv Hetil
Ano de publicação:
2015
Tipo de documento:
Article