Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.
Obesity (Silver Spring)
; 24(1): 231-7, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26554535
ABSTRACT
OBJECTIVE:
To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.METHODS:
Data are from a prospective cohort in Cincinnati, Ohio (HOME Study). Perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids were measured in prenatal serum samples. Differences were measured in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n = 204) and BMI between 2-8 years of age (n = 285) according to PFAS concentrations.RESULTS:
Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI 1.7, 6.9) and 3rd tercile (2.2; 95% CI -0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2 to 8 years compared to children in the 1st tercile (P < 0.05). PFOS, PFNA, and PFHxS were not associated with adiposity.CONCLUSIONS:
In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2-8 years.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Ácidos Sulfônicos
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Caprilatos
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Ácidos Alcanossulfônicos
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Obesidade Infantil
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Fluorocarbonos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Child
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Female
/
Humans
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Obesity (Silver Spring)
Ano de publicação:
2016
Tipo de documento:
Article