Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials.
Neurotherapeutics
; 13(1): 20-33, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26566961
ABSTRACT
B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antibody-producing cells and, most importantly, as sensors, coordinators, and regulators of the immune response. B cells, among other functions, regulate the T-cell activation process through their participation in antigen presentation and production of cytokines. The availability of monoclonal antibodies or fusion proteins against B-cell surface molecules or B-cell trophic factors bestows a rational approach for treating autoimmune neurological disorders, even when T cells are the main effector cells. This review summarizes basic aspects of B-cell biology, discusses the role(s) of B cells in neurological autoimmunity, and presents anti-B-cell drugs that are either currently on the market or are expected to be available in the near future for treating neurological autoimmune disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Doenças Autoimunes do Sistema Nervoso
Limite:
Humans
Idioma:
En
Revista:
Neurotherapeutics
Ano de publicação:
2016
Tipo de documento:
Article