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The role of innate immune signaling in the pathogenesis of atopic dermatitis and consequences for treatments.
Skabytska, Yuliya; Kaesler, Susanne; Volz, Thomas; Biedermann, Tilo.
Afiliação
  • Skabytska Y; Department of Dermatology and Allergology, TUM School of Medicine, Technische Universität München, Munich, Germany.
  • Kaesler S; Department of Dermatology, Eberhard-Karls-University Tübingen, Tübingen, Germany.
  • Volz T; Department of Dermatology and Allergology, TUM School of Medicine, Technische Universität München, Munich, Germany.
  • Biedermann T; Department of Dermatology, Eberhard-Karls-University Tübingen, Tübingen, Germany.
Semin Immunopathol ; 38(1): 29-43, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26573298
The skin is the largest organ at the interface between the environment and the host. Consequently, the skin plays a central role in mounting effective host defense. In addition to pathogens, the microbiota and the host immune system are in permanent contact and communication via the skin. Consequences of this permanent interaction are a unique and partly symbiotic relationship, a tight interdependence between these partners, and also a functional "setting the clock," in which, in the healthy steady state, an induction of protective responses to pathogens is guaranteed. At the same time, commensal microbes contribute to the alertness of the immune system and to the maintenance of immune tolerance. Atopic dermatitis (AD) is a chronic inflammatory skin disease based on a complex genetic trait with defects in cutaneous barrier, in stabilizing skin integrity. Most of AD patients develop deviated innate and adaptive immune responses. As a result, increased susceptibility to cutaneous infection is found in AD patients, and the interactions between these microbes and the skin participate in the development of chronic cutaneous inflammation. The role of the adaptive immune system was characterized in much detail, less though the contribution of innate immunity to AD pathogenesis. It is rather recent evidence that demonstrates a dominant role of components of the innate immune system not only for protecting from microbial invasion but also by orchestrating chronic skin inflammation. In this review we discuss the role of innate immune signaling and consecutive immune networks important for the pathogenesis and management of AD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Dermatite Atópica / Imunidade Inata Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Animals / Humans Idioma: En Revista: Semin Immunopathol Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Dermatite Atópica / Imunidade Inata Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Animals / Humans Idioma: En Revista: Semin Immunopathol Ano de publicação: 2016 Tipo de documento: Article