Potential role of the glycolytic oscillator in acute hypoxia in tumors.
Phys Med Biol
; 60(24): 9215-25, 2015 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-26576743
ABSTRACT
Tumor acute hypoxia has a dynamic component that is also, at least partially, coherent. Using blood oxygen level dependent magnetic resonance imaging, we observed coherent oscillations in hemoglobin saturation dynamics in cell line xenograft models of head and neck squamous cell carcinoma. We posit a well-established biochemical nonlinear oscillatory mechanism called the glycolytic oscillator as a potential cause of the coherent oscillations in tumors. These data suggest that metabolic changes within individual tumor cells may affect the local tumor microenvironment including oxygen availability and therefore radiosensitivity. These individual cells can synchronize the oscillations in patches of similar intermediate glucose levels. These alterations have potentially important implications for radiation therapy and are a potential target for optimizing the cancer response to radiation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Imageamento por Ressonância Magnética
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Carcinoma de Células Escamosas
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Microambiente Tumoral
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Glucose
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Neoplasias de Cabeça e Pescoço
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Hipóxia
Limite:
Animals
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Humans
Idioma:
En
Revista:
Phys Med Biol
Ano de publicação:
2015
Tipo de documento:
Article