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A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.
Zeller, Andreas; Tang, Leilei; Dertinger, Stephen D; Funk, Juergen; Duran-Pacheco, Gonzalo; Guérard, Melanie.
Afiliação
  • Zeller A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland and andreas.zeller@roche.com.
  • Tang L; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland and Present address: Qiagen Instruments, CH-8634 Hombrechtikon, Switzerland.
  • Dertinger SD; Litron Laboratories, Rochester, NY, USA.
  • Funk J; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland and.
  • Duran-Pacheco G; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland and.
  • Guérard M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland and.
Mutagenesis ; 31(3): 239-53, 2016 05.
Article em En | MEDLINE | ID: mdl-26590612
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adutos de DNA / Relação Dose-Resposta a Droga / Metanossulfonato de Metila / Testes de Mutagenicidade Limite: Animals Idioma: En Revista: Mutagenesis Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adutos de DNA / Relação Dose-Resposta a Droga / Metanossulfonato de Metila / Testes de Mutagenicidade Limite: Animals Idioma: En Revista: Mutagenesis Ano de publicação: 2016 Tipo de documento: Article