The Presence of Phage Orthologous Genes in Helicobacter pylori Correlates with the Presence of the Virulence Factors CagA and VacA.
Helicobacter
; 21(3): 226-33, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-26612095
ABSTRACT
BACKGROUND:
The bacterium Helicobacter pylori is associated with ulcers and the development of gastric cancer. Several genes, including cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), are associated with increased gastric cancer risk. Some strains of H. pylori also contain sequences related to bacteriophage phiHP33; however, the significance of these phage-related sequences remains unknown. MATERIALS ANDMETHODS:
We assessed the extent to which phiHP33-related sequences are present in 335 H. pylori strains using homology searches then mapped shared genes between phiHP33 and H. pylori strains onto an existing phylogeny.RESULTS:
One hundred and twenty-one H. pylori strains contain phage orthologous sequences, and the presence of the phage-related sequences correlates with the presence of CagA and VacA. Mapping of the phage orthologs onto a phylogeny of H. pylori is consistent with the hypothesis that these genes were acquired by horizontal gene transfer.CONCLUSIONS:
phiHP33 phage orthologous sequences might be of significance in understanding virulence of different H. pylori strains.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Úlcera Gástrica
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Proteínas de Bactérias
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Bacteriófagos
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Helicobacter pylori
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Infecções por Helicobacter
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Antígenos de Bactérias
Limite:
Humans
Idioma:
En
Revista:
Helicobacter
Ano de publicação:
2016
Tipo de documento:
Article