HDAC9, TWIST1 and FERD3L gene expression in asymptomatic stable and unstable carotid plaques.
Inflamm Res
; 65(4): 261-3, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26621503
ABSTRACT
BACKGROUND AND OBJECTIVES:
A variant located at the end of HDAC9 gene within clusters of DNAse I sensitivity zones and histone modification hotspots has been associated with large vessel stroke and could be linked to plaque instability. The aim of the study is to define if an altered expression of HDAC9, TWIST1 and FERD3L genes could be involved in plaque vulnerability.METHODS:
Histological classification and gene expression analysis were performed in 6 stable and 16 unstable plaques obtained from asymptomatic patients undergoing endarterectomy. Gene expression was analysed by real-time PCR. RESULTS ANDCONCLUSIONS:
TWIST1 gene expression resulted higher in stable plaques (P < 0.02). HDAC9 gene expression followed a similar trend (P = 0.11). These results highlighting the significant correlation between TWIST and HDAC9 gene expression suggest that both genes may contribute to plaque stability in a coordinated way.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Proteínas Nucleares
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Doenças das Artérias Carótidas
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Fatores de Regulação Miogênica
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Proteína 1 Relacionada a Twist
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Placa Aterosclerótica
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Histona Desacetilases
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Inflamm Res
Ano de publicação:
2016
Tipo de documento:
Article