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Facile synthesis of CdTe@GdS fluorescent-magnetic nanoparticles for tumor-targeted dual-modal imaging.
Zhang, Fei; Kong, Xiu-Qi; Li, Qiong; Sun, Ting-Ting; Chai, Chao; Shen, Wen; Hong, Zhang-Yong; He, Xi-Wen; Li, Wen-You; Zhang, Yu-Kui.
Afiliação
  • Zhang F; College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94
  • Kong XQ; State Key Laboratory of Medicinal Chemical Biology (Nankai University), College of Life Science, Nankai University, 94 Weijin Road, Tianjin 300071, China.
  • Li Q; The First Central Clinic College, Tianjin Medical University, and Department of Radiology, Tianjin First Central Hospital, 24 Fukang Road, Tianjin 300192, China.
  • Sun TT; College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94
  • Chai C; The First Central Clinic College, Tianjin Medical University, and Department of Radiology, Tianjin First Central Hospital, 24 Fukang Road, Tianjin 300192, China.
  • Shen W; The First Central Clinic College, Tianjin Medical University, and Department of Radiology, Tianjin First Central Hospital, 24 Fukang Road, Tianjin 300192, China.
  • Hong ZY; State Key Laboratory of Medicinal Chemical Biology (Nankai University), College of Life Science, Nankai University, 94 Weijin Road, Tianjin 300071, China.
  • He XW; College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94
  • Li WY; College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94
  • Zhang YK; College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94
Talanta ; 148: 108-15, 2016.
Article em En | MEDLINE | ID: mdl-26653430
Multimodal imaging has made great contribution for diagnosis and therapy of disease since it can provide more effective and complementary information in comparison to any single imaging modality. The design and fabrication of fluorescent-magnetic nanoparticles for multimodal imaging has rapidly developed over the years. Herein, we demonstrate the facile synthesis of GdS coated CdTe nanoparticles (CdTe@GdS NPs) as multimodal agents for fluorescence (FL) and T1-weighted magnetic resonance (MR) imaging. These nanoparticles obtain both prominent fluorescent and paramagnetic properties by coating the GdS shell on the surface of CdTe core via a simple room-temperature route in aqueous solution directly. It is shown that the as-prepared CdTe@GdS NPs have high quantum yield (QY) value of 12% and outstanding longitudinal relaxation rate (r1) of 11.25 mM s(-1), which allow them to be employed as FL/MR dual-modal imaging contrast agents. They also exhibit small particle size of 5 nm, excellent colloidal stability and low cellular toxicity for concentrations up to 750 µg mL(-1). In addition, with the conjugation of folic acid, the nanoparticles were successfully used for tumor-targeted FL/MR dual-modal imaging in vitro and in vivo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfetos / Compostos de Cádmio / Nanopartículas de Magnetita / Corantes Fluorescentes / Neoplasias Limite: Animals / Humans Idioma: En Revista: Talanta Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfetos / Compostos de Cádmio / Nanopartículas de Magnetita / Corantes Fluorescentes / Neoplasias Limite: Animals / Humans Idioma: En Revista: Talanta Ano de publicação: 2016 Tipo de documento: Article