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Urinary paraben concentrations and in vitro fertilization outcomes among women from a fertility clinic.
Mínguez-Alarcón, Lidia; Chiu, Yu-Han; Messerlian, Carmen; Williams, Paige L; Sabatini, Mary E; Toth, Thomas L; Ford, Jennifer B; Calafat, Antonia M; Hauser, Russ.
Afiliação
  • Mínguez-Alarcón L; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. Electronic address: lminguez@hsph.harvard.edu.
  • Chiu YH; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Messerlian C; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Williams PL; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Sabatini ME; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.
  • Toth TL; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Ford JB; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
  • Calafat AM; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Hauser R; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston,
Fertil Steril ; 105(3): 714-721, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26654974
ABSTRACT

OBJECTIVE:

To explore the relationship between urinary paraben concentrations and IVF outcomes among women attending an academic fertility center.

DESIGN:

Prospective cohort study.

SETTING:

Fertility clinic in a hospital setting. PATIENT(S) A total of 245 women contributing 356 IVF cycles. INTERVENTION(S) None. Quantification of urinary concentrations of parabens by isotope-dilution tandem mass spectrometry, and assessment of clinical endpoints of IVF treatments abstracted from electronic medical records at the academic fertility center. MAIN OUTCOME MEASURE(S) Total and mature oocyte counts, proportion of high-quality embryos, fertilization rates, and rates of implantation, clinical pregnancy, and live births. RESULT(S) The geometric means of the urinary concentrations of methylparaben, propylparaben, and butylparaben in our study population were 133, 24, and 1.5 µg/L, respectively. In models adjusted for age, body mass index, race/ethnicity, smoking status, and primary infertility diagnosis, urinary methylparaben, propylparaben, and butylparaben concentrations were not associated with IVF outcomes, specifically total and mature oocyte counts, proportion of high embryo quality, and fertilization rates. Moreover, no significant associations were found between urinary paraben concentrations and rates of implantation, clinical pregnancy, and live births. CONCLUSION(S) Urinary paraben concentrations were not associated with IVF outcomes among women undergoing infertility treatments.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Parabenos / Fertilização in vitro / Infertilidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: America do norte Idioma: En Revista: Fertil Steril Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Parabenos / Fertilização in vitro / Infertilidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: America do norte Idioma: En Revista: Fertil Steril Ano de publicação: 2016 Tipo de documento: Article