Urinary paraben concentrations and in vitro fertilization outcomes among women from a fertility clinic.
Fertil Steril
; 105(3): 714-721, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26654974
ABSTRACT
OBJECTIVE:
To explore the relationship between urinary paraben concentrations and IVF outcomes among women attending an academic fertility center.DESIGN:
Prospective cohort study.SETTING:
Fertility clinic in a hospital setting. PATIENT(S) A total of 245 women contributing 356 IVF cycles. INTERVENTION(S) None. Quantification of urinary concentrations of parabens by isotope-dilution tandem mass spectrometry, and assessment of clinical endpoints of IVF treatments abstracted from electronic medical records at the academic fertility center. MAIN OUTCOME MEASURE(S) Total and mature oocyte counts, proportion of high-quality embryos, fertilization rates, and rates of implantation, clinical pregnancy, and live births. RESULT(S) The geometric means of the urinary concentrations of methylparaben, propylparaben, and butylparaben in our study population were 133, 24, and 1.5 µg/L, respectively. In models adjusted for age, body mass index, race/ethnicity, smoking status, and primary infertility diagnosis, urinary methylparaben, propylparaben, and butylparaben concentrations were not associated with IVF outcomes, specifically total and mature oocyte counts, proportion of high embryo quality, and fertilization rates. Moreover, no significant associations were found between urinary paraben concentrations and rates of implantation, clinical pregnancy, and live births. CONCLUSION(S) Urinary paraben concentrations were not associated with IVF outcomes among women undergoing infertility treatments.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Parabenos
/
Fertilização in vitro
/
Infertilidade
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2016
Tipo de documento:
Article