Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation.

Li, Minghui; Kales, Stephen C; Ma, Ke; Shoemaker, Benjamin A; Crespo-Barreto, Juan; Cangelosi, Andrew L; Lipkowitz, Stanley; Panchenko, Anna R

Li, Minghui; Kales, Stephen C; Ma, Ke; Shoemaker, Benjamin A; Crespo-Barreto, Juan; Cangelosi, Andrew L; Lipkowitz, Stanley; Panchenko, Anna R.

Afiliação

Li M; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland.
Kales SC; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Ma K; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Shoemaker BA; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland.
Crespo-Barreto J; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Cangelosi AL; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Lipkowitz S; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. panch@ncbi.nlm.nih.gov lipkowis@mail.nih.gov.
Panchenko AR; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland. panch@ncbi.nlm.nih.gov lipkowis@mail.nih.gov.

Cancer Res ; 76(3): 561-71, 2016 Feb 01.

Article em En | MEDLINE | ID: mdl-26676746

Assuntos

Neoplasias Pulmonares/enzimologia; Neoplasias Pulmonares/genética; Mutação de Sentido Incorreto; Proteínas Proto-Oncogênicas c-cbl/genética; Proteínas Proto-Oncogênicas c-cbl/metabolismo; Neoplasias do Colo do Útero/enzimologia; Neoplasias do Colo do Útero/genética; Carcinoma Pulmonar de Células não Pequenas/enzimologia; Carcinoma Pulmonar de Células não Pequenas/genética; Ativação Enzimática; Receptores ErbB/química; Receptores ErbB/metabolismo; Feminino; Células HEK293; Células HeLa; Humanos; Modelos Moleculares; Fosforilação; Estabilidade Proteica; Proteínas Proto-Oncogênicas c-cbl/química; Transdução de Sinais; Termodinâmica; Transfecção; Ubiquitinação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Mutação de Sentido Incorreto / Proteínas Proto-Oncogênicas c-cbl / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2016 Tipo de documento: Article

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