Gasotransmitters in cancer: from pathophysiology to experimental therapy.
Nat Rev Drug Discov
; 15(3): 185-203, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26678620
ABSTRACT
The three endogenous gaseous transmitters - nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) - regulate a number of key biological functions. Emerging data have revealed several new mechanisms for each of these three gasotransmitters in tumour biology. It is now appreciated that they show bimodal pharmacological character in cancer, in that not only the inhibition of their biosynthesis but also elevation of their concentration beyond a certain threshold can exert anticancer effects. This Review discusses the role of each gasotransmitter in cancer and the effects of pharmacological agents - some of which are in early-stage clinical studies - that modulate the levels of each gasotransmitter. A clearer understanding of the pharmacological character of these three gases and the mechanisms underlying their biological effects is expected to guide further clinical translation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapias em Estudo
/
Gasotransmissores
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Drug Discov
Ano de publicação:
2016
Tipo de documento:
Article