&#945;-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1&#945; and STAT3 signaling pathways.

Wen, Zhengde; Huang, Chaohao; Xu, Yaya; Xiao, Yuwu; Tang, Lili; Dai, Juji; Sun, Hongwei; Chen, Bicheng; Zhou, Mengtao

α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways.

Wen, Zhengde; Huang, Chaohao; Xu, Yaya; Xiao, Yuwu; Tang, Lili; Dai, Juji; Sun, Hongwei; Chen, Bicheng; Zhou, Mengtao.

Afiliação

Wen Z; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Huang C; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xu Y; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiao Y; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tang L; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, China.
Dai J; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Sun H; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chen B; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, China.
Zhou M; Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Eur J Pharmacol ; 771: 93-8, 2016 Jan 15.

Article em En | MEDLINE | ID: mdl-26688571

Assuntos

Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Fator de Transcrição STAT3/efeitos dos fármacos; Solanina/farmacologia; Fator A de Crescimento do Endotélio Vascular/biossíntese; Caderinas/biossíntese; Caderinas/genética; Linhagem Celular Tumoral; Cobalto/farmacologia; Técnicas de Cocultura; Regulação para Baixo; Humanos; Fator 1 Induzível por Hipóxia/biossíntese; Fator 1 Induzível por Hipóxia/genética; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/genética; Transdução de Sinais/efeitos dos fármacos; Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores

Palavras-chave

HIF-1α; Pancreatic cancer; STAT3; VEGF; α-solanine; α-solanine (PubChem CID: 262500)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solanina / Sistema de Sinalização das MAP Quinases / Fator A de Crescimento do Endotélio Vascular / Fator de Transcrição STAT3 Limite: Humans Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2016 Tipo de documento: Article

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