Immunohistochemical expression of matrix metalloproteinases in ameloblastomas and pericoronal follicles.
J Oral Pathol Med
; 45(8): 586-90, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-26694521
ABSTRACT
BACKGROUND:
Ameloblastoma (AM) is a benign odontogenic neoplasm characterized by local invasiveness and recurrence. We compared the immunohistochemical expression of matrix metalloproteinases in different clinical types of AM as well as in normal odontogenic tissue.METHODS:
Thirteen cases of solid AMs, five cases of unicystic AM and eight pericoronal follicles (PF) were selected and subjected to immunohistochemical investigation for matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions.RESULTS:
The expressions of MMP-1 and MMP-2 were very high in the cytoplasm of cells throughout the entire epithelium and in fibroblasts from the adjacent connective tissue. MMP-9 expression was observed in the same location although with weaker staining. The Kruskal-Wallis test showed statistically significant differences in the epithelial expressions of MMP-1 and MMP-2; there was lower expression among solid AMs when compared with unicystic AM and PF. Compared to both types of AM, higher stromal expression of MMP-9 was found in PF.CONCLUSION:
MMP-1, MMP-2 and MMP-9 seem to be associated with AM tumour behaviour as well as physiological tissue remodelling within PF.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ameloblastoma
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Neoplasias Maxilomandibulares
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Tumores Odontogênicos
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Metaloproteinases da Matriz
/
Saco Dentário
Limite:
Humans
Idioma:
En
Revista:
J Oral Pathol Med
Ano de publicação:
2016
Tipo de documento:
Article