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Oral administration of synthetic porcine beta-defensin-2 improves growth performance and cecal microbial flora and down-regulates the expression of intestinal toll-like receptor-4 and inflammatory cytokines in weaned piglets challenged with enterotoxigenic Escherichia coli.
Tang, Zhiru; Xu, Ling; Shi, Baoshi; Deng, Huang; Lai, Xin; Liu, Jingyan; Sun, Zhihong.
Afiliação
  • Tang Z; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China. tangzhiru2326@sina.com.cn.
  • Xu L; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China.
  • Shi B; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China.
  • Deng H; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China.
  • Lai X; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China.
  • Liu J; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China.
  • Sun Z; Key Laboratory for Bio-feed and Molecular Nutrition, Southwest University, Chongqing, China. sunzh2002cn@aliyun.com.
Anim Sci J ; 87(10): 1258-1266, 2016 Oct.
Article em En | MEDLINE | ID: mdl-26707031
Synthetic porcine beta-defensin-2 (pBD-2) was tested as an alternative to antimicrobial growth-promoters in pig production. Thirty 21-day weaned piglets were challenged with enterotoxigenic Escherichia coli, and orally dosed with either sterile water (CON), pBD-2 (BD) or neomycin sulphate (NS) twice daily for 21 days. pBD-2 and NS led to higher growth performance, jejunum villus height and increased expression of insulin-like growth factor-I compared with the CON group (P < 0.05). Hemolytic E. coli scores from rectal swabs, and copy numbers of E. coli, Bacteroides fragilis and Streptococcus in the cecal digesta of the BD- or NS-treated piglets were lower than those in the CON group (P < 0.05). Messenger RNA levels of toll-like receptor 4, tumor necrosis factor-α, interleukin (IL)-1ß, and IL-8 in the jejunum mucosa of the BD and NS groups were lower than those in the CON group (P < 0.05). Copy numbers of Lactobacilli and Bifidobacteria in the cecal digesta of the BD group were higher than those of the CON and NS groups (P < 0.05). Therefore, pBD-2 has antimicrobial activity in piglets, and it can improve growth performance, reduce inflammatory cytokine expression and affect intestinal morphological indices in the same way as probiotics. © 2015 Japanese Society of Animal Science.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Suínos / Regulação para Baixo / Expressão Gênica / Ceco / Citocinas / Mediadores da Inflamação / Beta-Defensinas / Receptor 4 Toll-Like / Escherichia coli Enterotoxigênica / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Anim Sci J Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Suínos / Regulação para Baixo / Expressão Gênica / Ceco / Citocinas / Mediadores da Inflamação / Beta-Defensinas / Receptor 4 Toll-Like / Escherichia coli Enterotoxigênica / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Anim Sci J Ano de publicação: 2016 Tipo de documento: Article