Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems.
Bioorg Med Chem Lett
; 26(3): 941-945, 2016 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-26739777
ABSTRACT
The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic ß-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Celulose
/
Curcumina
/
Beta-Ciclodextrinas
/
Nanopartículas
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2016
Tipo de documento:
Article