Neuroendocrine phenotype as an acquired resistance mechanism in ALK-rearranged lung adenocarcinoma.

Caumont, Charline; Veillon, Rémi; Gros, Audrey; Laharanne, Elodie; Bégueret, Hugues; Merlio, Jean-Philippe

Caumont, Charline; Veillon, Rémi; Gros, Audrey; Laharanne, Elodie; Bégueret, Hugues; Merlio, Jean-Philippe.

Afiliação

Caumont C; Laboratory of Tumor Biology, University Hospital of Bordeaux, F-33604, Pessac, France; EA2406, Histology and Molecular Pathology of Tumors, Univ. Bordeaux, F-33076 Bordeaux, France. Electronic address: charline.caumont@chu-bordeaux.fr.
Veillon R; Department of Pneumology, University Hospital of Bordeaux, F-33604, Pessac, France.
Gros A; Laboratory of Tumor Biology, University Hospital of Bordeaux, F-33604, Pessac, France; EA2406, Histology and Molecular Pathology of Tumors, Univ. Bordeaux, F-33076 Bordeaux, France.
Laharanne E; Laboratory of Tumor Biology, University Hospital of Bordeaux, F-33604, Pessac, France.
Bégueret H; Department of Pathology, University Hospital of Bordeaux, F-33604, Pessac, France.
Merlio JP; Laboratory of Tumor Biology, University Hospital of Bordeaux, F-33604, Pessac, France; EA2406, Histology and Molecular Pathology of Tumors, Univ. Bordeaux, F-33076 Bordeaux, France.

Lung Cancer ; 92: 15-8, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26775590

Assuntos

Adenocarcinoma/enzimologia; Adenocarcinoma/patologia; Neoplasias Pulmonares/enzimologia; Neoplasias Pulmonares/patologia; Tumores Neuroendócrinos/patologia; Receptores Proteína Tirosina Quinases/genética; Adenocarcinoma/tratamento farmacológico; Adenocarcinoma/genética; Adenocarcinoma de Pulmão; Quinase do Linfoma Anaplásico; Clavícula/patologia; Crizotinibe; Resistencia a Medicamentos Antineoplásicos; Feminino; Rearranjo Gênico; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Pessoa de Meia-Idade; Inibidores de Proteínas Quinases/uso terapêutico; Pirazóis/uso terapêutico; Piridinas/uso terapêutico; Receptores Proteína Tirosina Quinases/metabolismo

Palavras-chave

ALK; Adenocarcinoma; Crizotinib; Neuroendocrine; Non-small cell lung carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Receptores Proteína Tirosina Quinases / Tumores Neuroendócrinos / Neoplasias Pulmonares Limite: Female / Humans / Middle aged Idioma: En Revista: Lung Cancer Ano de publicação: 2016 Tipo de documento: Article

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