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Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia.
Kragh-Hansen, Ulrich; Minchiotti, Lorenzo; Coletta, Andrea; Bienk, Konrad; Galliano, Monica; Schiøtt, Birgit; Iwao, Yasunori; Ishima, Yu; Otagiri, Masaki.
Afiliação
  • Kragh-Hansen U; Department of Biomedicine, University of Aarhus, DK-8000 Aarhus C, Denmark. Electronic address: ukh@biomed.au.dk.
  • Minchiotti L; Department of Molecular Medicine, University of Pavia, I-27100 Pavia, Italy.
  • Coletta A; Department of Chemistry and Interdisciplinary Nanoscience Center, University of Aarhus, DK-8000 Aarhus C, Denmark.
  • Bienk K; Department of Molecular Biology & Genetics and Interdisciplinary Nanoscience Center, University of Aarhus, DK-8000 Aarhus C, Denmark.
  • Galliano M; Department of Molecular Medicine, University of Pavia, I-27100 Pavia, Italy.
  • Schiøtt B; Department of Chemistry and Interdisciplinary Nanoscience Center, University of Aarhus, DK-8000 Aarhus C, Denmark.
  • Iwao Y; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
  • Ishima Y; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
  • Otagiri M; Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Biochim Biophys Acta ; 1860(4): 648-60, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26777880
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiroxina / Albumina Sérica / Hipertireoxinemia Disalbuminêmica Familiar / Simulação de Dinâmica Molecular / Simulação de Acoplamento Molecular / Mutação Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiroxina / Albumina Sérica / Hipertireoxinemia Disalbuminêmica Familiar / Simulação de Dinâmica Molecular / Simulação de Acoplamento Molecular / Mutação Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article