Safety of long acting muscarinic antagonists: are all these drugs always and equally safe?
Curr Med Res Opin
; 32(5): 975-7, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-26789695
ABSTRACT
Inhaled bronchodilators - such as long-acting muscarinic receptor antagonists (LAMAs) - are central to the pharmacological management of symptomatic chronic obstructive pulmonary disease. LAMAs are considered to be safe drugs at recommended dosages. In the present issue of the Journal safety of umeclidinium, a recently marketed LAMA, at twice the recommended dosage, has been evaluated with good results in a Japanese, COPD population. However, because muscarinic receptors are expressed not only in the lungs but also at the level of heart, digestive and urinary apparatus, the potential exists for LAMAs to cause adverse events related to stimulation of receptors in these organs. Head-to-head and post-marketing vigilance studies are required to determine the profile risk of these drugs, ultimately, and whether differences exist between currently available LAMAs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinuclidinas
/
Antagonistas Muscarínicos
/
Doença Pulmonar Obstrutiva Crônica
Limite:
Humans
Idioma:
En
Revista:
Curr Med Res Opin
Ano de publicação:
2016
Tipo de documento:
Article