What is the best treatment for women with polycystic ovarian syndrome and high LH/FSH ratio? A comparison among in vitro fertilization with GnRH agonist, GnRH antagonist and in vitro maturation.
J Endocrinol Invest
; 39(7): 799-803, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-26797707
ABSTRACT
PURPOSE:
To evaluate whether high LH/FSH ratio has a clinical impact on patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) with GnRH-agonist/antagonist protocols or in vitro maturation (IVM) treatments.METHODS:
We retrospectively reviewed all PCOS patients with day 3 LH/FSH ratio ≥1.5 who underwent IVF or IVM. The main outcomes measures were embryo quality and pregnancy rate.RESULTS:
A total of 75 cycles were included. Among these, 44 patients underwent long agonist protocol, 16 antagonist protocol and 15 IVM. Age, basal LH and FSH levels, as well as duration of infertility were comparable for all groups. The LH level on the day of hCG administration was significantly lower in the antagonist group (0.9 IU/ml) compared to the long agonist group (1.4 IU/ml, p = 0.01). There was no difference in pregnancy rates among the groups 27.2 % in the long agonist group, 37.5 % in the antagonist group and 26.6 % among the IVM patients.CONCLUSIONS:
High LH/FSH ratio had no adverse effect on pregnancy rates in all three treatment modes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
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Hormônio Luteinizante
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Fertilização in vitro
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Técnicas de Maturação in Vitro de Oócitos
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Hormônio Foliculoestimulante
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Antagonistas de Hormônios
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Infertilidade Feminina
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Guideline
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2016
Tipo de documento:
Article