New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs.
Pharmacogenomics
; 17(3): 277-96, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26799749
ABSTRACT
Interindividual variability in immunosuppressive drug responses might be partly explained by genetic variants in proteins involved in the immune response or associated with IS pharmacodynamics. On a general basis, the pharmacogenetics of drug target proteins is less known and understood than that of proteins involved in drug disposition pathways. The aim of this review is to facilitate research related to the pharmacodynamics of the main immunosuppressive drugs used in solid organ transplantation. We elaborated a quality of evidence grading system based on a literature review and identified 'highly recommended', 'recommended' or 'potential' candidates for further research. It is likely that a number of additional rare variants might further explain drug response phenotypes in transplantation, and particularly the most severe ones. The advent of next-generation sequencing will help to identify those variants.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
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Transplante de Órgãos
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Polimorfismo de Nucleotídeo Único
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Loci Gênicos
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Serina-Treonina Quinases TOR
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Inibidores de Calcineurina
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Imunossupressores
Limite:
Humans
Idioma:
En
Revista:
Pharmacogenomics
Ano de publicação:
2016
Tipo de documento:
Article