Survey of the use of domperidone and the association with QTc prolongation in general practice.
Postgrad Med J
; 92(1089): 390-2, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-26802127
ABSTRACT
PURPOSE OF THE STUDY Domperidone is associated with QTc prolongation, predisposing to the development of ventricular arrhythmias. In 2014, The Medicines and Healthcare Regulatory Agency (MHRA) recommended restricting its use. We assessed whether these recommendations have been implemented in a general practice. STUDY DESIGN:
We conducted a prospective study using the general practitioner (GP) computer database on patients who had at least one repeat prescription for domperidone in 12â months. Data were presented to the doctors and the survey was repeated 7â months later.RESULTS:
Sixty-four patients (mean age 61.3±16.4â years) were identified who had received at least one repeat prescription of domperidone. Twenty patients were being prescribed over the recommended daily dose. Nineteen patients were coprescribed medications known to prolong the QTc interval and two CYP3A4 inhibitors. The repeat survey performed 7â months later demonstrated a 70% reduction in the number of patients prescribed domperidone to a total of 19 (three patients prescribed above the recommended dose) none of which had a history of cardiac disease or were being coprescribed drugs known to prolong the QTc interval.CONCLUSIONS:
Following the publication of the MHRA recommendations and presentation of our initial survey, there has been a significant reduction in the number of patients treated with domperidone and those coprescribed drugs known to prolong the QTc interval. We suggest that regular review of GP practice database should be performed to identify those patients prescribed domperidone and at risk of life-threatening arrhythmias and measures taken to use alternative pharmacological agents.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Padrões de Prática Médica
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Síndrome do QT Longo
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Domperidona
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Prescrição Inadequada
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Medicina Geral
Tipo de estudo:
Diagnostic_studies
/
Guideline
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Postgrad Med J
Ano de publicação:
2016
Tipo de documento:
Article