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Study of breakthrough cancer pain in an animal model induced by endothelin-1.
Tang, Yixun; Peng, Hao; Liao, Qian; Gan, Li; Zhang, Raoxiang; Huang, Lihua; Ding, Zhigang; Yang, Hui; Yan, Xuebin; Gu, Yonghong; Zang, Xiaofang; Huang, Dong; Cao, Shousong.
Afiliação
  • Tang Y; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Peng H; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Liao Q; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Gan L; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Zhang R; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Huang L; Medical Experimental Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  • Ding Z; Medical Experimental Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  • Yang H; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Yan X; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
  • Gu Y; Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  • Zang X; Department of Orthopaedics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  • Huang D; Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China. Electronic address: huangdong6619@vip.163.com.
  • Cao S; Department of Pharmacology, School of Pharmacy, Sichuan Medical University, Luzhou, Sichuan Province, China; Visiting Professor, Central South University, Changsha, Hunan Province, China. Electronic address: shousongc@gmail.com.
Neurosci Lett ; 617: 108-15, 2016 Mar 23.
Article em En | MEDLINE | ID: mdl-26828300
ABSTRACT
Cancer patients with bone metastases often suffer breakthrough pain. However, little progress has been made in the treatment of breakthrough pain and its associated mechanism(s) in the patient with cancer due to lacking of resembling and predictive animal models. We previously have demonstrated that endothelin-1 plays an important role in breakthrough cancer pain. In the present study, we have established an animal model of breakthrough cancer pain induced by endothelin-1. The animal model of breakthrough cancer pain is strictly followed the definition and meets the characteristics of breakthrough pain. The model is reliable, reproducible and easy to be produced. To our knowledge, this is the first report for establishing such an animal model. In addition, we also found that a selective ETA receptor antagonist BQ-123 could reverse endothelin-1 induced breakthrough pain. We further studied the characteristics of pain behaviors such as hind limb use score and voluntary wheel running as well as the electrophysiology of sciatic nerve fibers with the model. The murine model shows high resemblance compared to the breakthrough cancer pain in the patients with cancer clinically. It provides a platform for further study of the pathogenesis of breakthrough cancer pain and targeted intervention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotelina-1 / Modelos Animais de Doenças / Dor Irruptiva / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotelina-1 / Modelos Animais de Doenças / Dor Irruptiva / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2016 Tipo de documento: Article