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Synthesis and Cytoxicity of Sempervirine and Analogues.
Pan, Xiaohong; Yang, Chunying; Cleveland, John L; Bannister, Thomas D.
Afiliação
  • Pan X; Department of Chemistry, The Scripps Research Institute , Jupiter, Florida 33458, United States.
  • Yang C; Department of Tumor Biology, Moffitt Cancer Center & Research Institute , Tampa, Florida 33612, United States.
  • Cleveland JL; Department of Tumor Biology, Moffitt Cancer Center & Research Institute , Tampa, Florida 33612, United States.
  • Bannister TD; Department of Chemistry, The Scripps Research Institute , Jupiter, Florida 33458, United States.
J Org Chem ; 81(5): 2194-200, 2016 Mar 04.
Article em En | MEDLINE | ID: mdl-26828413
Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure-activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Alcaloides de Triptamina e Secologanina / Antineoplásicos Limite: Humans Idioma: En Revista: J Org Chem Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Alcaloides de Triptamina e Secologanina / Antineoplásicos Limite: Humans Idioma: En Revista: J Org Chem Ano de publicação: 2016 Tipo de documento: Article