Fast and Reliable Quantitative Peptidomics with labelpepmatch.
J Proteome Res
; 15(3): 1080-9, 2016 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-26828777
ABSTRACT
The use of stable isotope tags in quantitative peptidomics offers many advantages, but the laborious identification of matching sets of labeled peptide peaks is still a major bottleneck. Here we present labelpepmatch, an R-package for fast and straightforward analysis of LC-MS spectra of labeled peptides. This open-source tool offers fast and accurate identification of peak pairs alongside an appropriate framework for statistical inference on quantitative peptidomics data, based on techniques from other -omics disciplines. A relevant case study on the desert locust Schistocerca gregaria proves our pipeline to be a reliable tool for quick but thorough explorative analyses.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Software
/
Proteínas de Insetos
Limite:
Animals
Idioma:
En
Revista:
J Proteome Res
Ano de publicação:
2016
Tipo de documento:
Article