Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel.
Anticancer Agents Med Chem
; 16(7): 875-80, 2016.
Article
em En
| MEDLINE
| ID: mdl-26830032
ABSTRACT
Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Taxoides
Limite:
Humans
Idioma:
En
Revista:
Anticancer Agents Med Chem
Ano de publicação:
2016
Tipo de documento:
Article