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Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful ß-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal ß-galactosidase.
Thonhofer, Martin; Weber, Patrick; Santana, Andres Gonzalez; Fischer, Roland; Pabst, Bettina M; Paschke, Eduard; Schalli, Michael; Stütz, Arnold E; Tschernutter, Marion; Windischhofer, Werner; Withers, Stephen G.
Afiliação
  • Thonhofer M; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
  • Weber P; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
  • Santana AG; Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
  • Fischer R; Institute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
  • Pabst BM; Laboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
  • Paschke E; Laboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
  • Schalli M; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria.
  • Stütz AE; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. Electronic address: stuetz@tugraz.at.
  • Tschernutter M; Laboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
  • Windischhofer W; Laboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria.
  • Withers SG; Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Bioorg Med Chem Lett ; 26(5): 1438-42, 2016 Mar 01.
Article em En | MEDLINE | ID: mdl-26838810
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gangliosidose GM1 / Beta-Galactosidase / Inibidores Enzimáticos / Imino Piranoses / Lisossomos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gangliosidose GM1 / Beta-Galactosidase / Inibidores Enzimáticos / Imino Piranoses / Lisossomos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article