Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease.

Kuter, Katarzyna; Kratochwil, Manuela; Berghauzen-Maciejewska, Klemencja; Glowacka, Urszula; Sugawa, Michiru D; Ossowska, Krystyna; Dencher, Norbert A

Kuter, Katarzyna; Kratochwil, Manuela; Berghauzen-Maciejewska, Klemencja; Glowacka, Urszula; Sugawa, Michiru D; Ossowska, Krystyna; Dencher, Norbert A.

Afiliação

Kuter K; Department of Neuropsychopharmacology, Polish Academy of Sciences, Smetna St. 12, 31-343 Kraków, Poland. Electronic address: kuter@if-pan.krakow.pl.
Kratochwil M; Physical Biochemistry, Department of Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, D-64287 Darmstadt, Germany.
Berghauzen-Maciejewska K; Department of Neuropsychopharmacology, Polish Academy of Sciences, Smetna St. 12, 31-343 Kraków, Poland.
Glowacka U; Department of Neuropsychopharmacology, Polish Academy of Sciences, Smetna St. 12, 31-343 Kraków, Poland.
Sugawa MD; Physical Biochemistry, Department of Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, D-64287 Darmstadt, Germany; Clinical Neurobiology, Charité-Universitätsmedizin, D-12203 Berlin, Germany.
Ossowska K; Department of Neuropsychopharmacology, Polish Academy of Sciences, Smetna St. 12, 31-343 Kraków, Poland.
Dencher NA; Physical Biochemistry, Department of Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, D-64287 Darmstadt, Germany.

Biochim Biophys Acta ; 1862(4): 741-753, 2016 04.

Article em En | MEDLINE | ID: mdl-26844379

Assuntos

Membrana Celular/metabolismo; Neurônios Dopaminérgicos/metabolismo; Mitocôndrias/metabolismo; Fosforilação Oxidativa/efeitos dos fármacos; Oxidopamina/efeitos adversos; Doença de Parkinson Secundária/metabolismo; Animais; Membrana Celular/patologia; Neurônios Dopaminérgicos/patologia; Masculino; Mitocôndrias/patologia; Proteínas Mitocondriais/metabolismo; Oxidopamina/farmacologia; Doença de Parkinson Secundária/patologia; Ratos; Ratos Wistar

Palavras-chave

Compensatory processes; Mitochondrial membrane viscosity; Neurodegeneration; OxPhos supercomplex assembly; Parkinson's disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / Doença de Parkinson Secundária / Membrana Celular / Oxidopamina / Neurônios Dopaminérgicos / Mitocôndrias Tipo de estudo: Prognostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article

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