Piperine containing floating microspheres: an approach for drug targeting to the upper gastrointestinal tract.
Drug Deliv Transl Res
; 6(3): 299-307, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26902907
ABSTRACT
The purpose of this investigation was to prepare and characterize acyclovir loaded floating microspheres by emulsification solvent evaporation method. Piperine was added to investigate its effect on acyclovir bioavailability. The microspheres were characterized for size, shape, entrapment efficiency, in vitro drug release, and in vivo pharmacokinetic parameters. The morphological characterization of microspheres was done using a scanning electron microscope. The microspheres were spherical and had particle size in the range of 400 to 525 µm. The percent drug entrapment efficiency varied between 56.12 ± 1.32 % to 87.32 ± 5.28 %. The drug release was decreased at higher polymer concentrations. Nearly two times higher AUC0-24 value of acyclovir-loaded piperine containing microspheres (15614.13 ± 6953.13 ng h ml(-1)) was observed as compared to the drug solution (7552.33 ± 3219.09 ng h ml(-1)). Under the accelerated storage conditions, the best selected formulation was found to be stable for 90 days. The preliminary results of this study suggest that the developed microspheres containing acyclovir could enhance drug entrapment efficiency, reduce initial burst release, and prolong the drug release with enhanced bioavailability.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
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Aciclovir
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Sistemas de Liberação de Medicamentos
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Trato Gastrointestinal Superior
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Alcaloides
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Benzodioxóis
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Alcamidas Poli-Insaturadas
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Microesferas
Limite:
Animals
Idioma:
En
Revista:
Drug Deliv Transl Res
Ano de publicação:
2016
Tipo de documento:
Article