Substitutions mimicking deimination and phosphorylation of 18.5-kDa myelin basic protein exert local structural effects that subtly influence its global folding.

Vassall, Kenrick A; Bamm, Vladimir V; Jenkins, Andrew D; Velte, Caroline J; Kattnig, Daniel R; Boggs, Joan M; Hinderberger, Dariush; Harauz, George

Vassall, Kenrick A; Bamm, Vladimir V; Jenkins, Andrew D; Velte, Caroline J; Kattnig, Daniel R; Boggs, Joan M; Hinderberger, Dariush; Harauz, George.

Afiliação

Vassall KA; Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
Bamm VV; Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
Jenkins AD; Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
Velte CJ; Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada; Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
Kattnig DR; Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
Boggs JM; Molecular Structure and Function Program, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada.
Hinderberger D; Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
Harauz G; Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada. Electronic address: gharauz@uoguelph.ca.

Biochim Biophys Acta ; 1858(6): 1262-77, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26903219

Assuntos

Iminas/metabolismo; Proteína Básica da Mielina/metabolismo; Adsorção; Sequência de Aminoácidos; Dicroísmo Circular; Transferência Ressonante de Energia de Fluorescência; Dados de Sequência Molecular; Proteína Básica da Mielina/química; Fosforilação; Dobramento de Proteína; Proteólise; Espectrometria de Fluorescência; Lipossomas Unilamelares

Palavras-chave

Amphipathic α-helix; Calmodulin; Cathepsin D; Circular dichroism (CD) spectroscopy; Citrullination/deimination; DEER spectroscopy; Förster (fluorescence) resonance energy transfer (FRET); Intrinsically-disordered protein; Molecular recognition fragment (MoRF); Myelin basic protein (MBP); Phosphorylation; Protein folding intermediate

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Básica da Mielina / Iminas Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google