The tetraspanin TSP3 of Neurospora crassa is a vacuolar membrane protein and shares characteristics with IDI proteins.
Mycologia
; 108(3): 581-9, 2016.
Article
em En
| MEDLINE
| ID: mdl-26908649
ABSTRACT
The fungal vacuole is an organelle, which adopts pleiotropic morphologies and functions. In aging and starving hyphae it is the compartment of degradation and recycling of cellular constituents. Here we identified TSP3, one of three tetraspanins present in the filamentous ascomycete fungus Neurospora crassa, as a vacuolar membrane protein. The protein is detected only in aging and starving cultures and under other conditions, which induce autophagy, such as vegetative incompatibility or the presence of the macrolide antibiotic rapamycin. Mutant analysis revealed that TSP3 is dispensable for growth and development of the fungus under laboratory conditions. Together these findings indicate that tsp3 shares characteristics with idi (induced during incompatibility) genes and might promote vacuolar functions related to autophagy.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacúolos
/
Proteínas Fúngicas
/
Tetraspaninas
/
Proteínas de Membrana
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Neurospora crassa
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Mycologia
Ano de publicação:
2016
Tipo de documento:
Article