Association of downregulated HDAC 2 with the impaired mitochondrial function and cytokine secretion in the monocytes/macrophages from gestational diabetes mellitus patients.

Qu, Xin; Yu, Hongna; Jia, Bei; Yu, Xiaoyan; Cui, Qing; Liu, Zhifen; Sun, Chengming; Chu, Yongli

Qu, Xin; Yu, Hongna; Jia, Bei; Yu, Xiaoyan; Cui, Qing; Liu, Zhifen; Sun, Chengming; Chu, Yongli.

Afiliação

Qu X; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Yu H; Department of Ultrasonography, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Jia B; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Yu X; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Cui Q; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Liu Z; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Sun C; Clinical laboratory, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.
Chu Y; Department of Obstetrics and Gynecology, the Affiliated Yantai Yuhuangding Hospital of Medical College, Qingdao University, Yantai 264000, Shandong, China.

Cell Biol Int ; 40(6): 642-51, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26936353

Assuntos

Citocinas/metabolismo; Diabetes Gestacional/sangue; Histona Desacetilase 2/metabolismo; Macrófagos/metabolismo; Mitocôndrias/metabolismo; Monócitos/metabolismo; Adulto; Citocinas/sangue; Diabetes Gestacional/enzimologia; Diabetes Gestacional/genética; Regulação para Baixo; Feminino; Histona Desacetilase 2/sangue; Histona Desacetilase 2/genética; Inibidores de Histona Desacetilases/farmacologia; Humanos; Interleucina-1beta/sangue; Interleucina-6/sangue; Macrófagos/enzimologia; Mitocôndrias/imunologia; Monócitos/enzimologia; Fenilbutiratos/farmacologia; Gravidez; Espécies Reativas de Oxigênio/metabolismo; Fator de Necrose Tumoral alfa/sangue

Palavras-chave

gestational diabetes mellitus (GDM); histone deacetylase (HDAC) 2; mitochondrial dysfunction (MD); monocytes/macrophages; proinflamatory cytokine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monócitos / Citocinas / Diabetes Gestacional / Histona Desacetilase 2 / Macrófagos / Mitocôndrias Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Cell Biol Int Ano de publicação: 2016 Tipo de documento: Article

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