Tracking HSC Origin: From Bench to Placenta.

Calvanese, Vincenzo; Mikkola, Hanna K A

Calvanese, Vincenzo; Mikkola, Hanna K A.

Afiliação

Calvanese V; Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
Mikkola HK; Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: hmikkola@mcdb.ucla.edu.

Dev Cell ; 36(5): 479-80, 2016 Mar 07.

Article em En | MEDLINE | ID: mdl-26954540

ABSTRACT

ABSTRACT

Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and embryo. The cells mature into transplantable HSCs in culture.

Assuntos

Diferenciação Celular/fisiologia; Linhagem da Célula/fisiologia; Reprogramação Celular; Hematopoese/genética; Células-Tronco Hematopoéticas/citologia; Células-Tronco Embrionárias Murinas/citologia; Animais; Feminino; Gravidez

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Diferenciação Celular / Linhagem da Célula / Reprogramação Celular / Células-Tronco Embrionárias Murinas / Hematopoese Limite: Animals / Pregnancy Idioma: En Revista: Dev Cell Ano de publicação: 2016 Tipo de documento: Article

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