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Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy.
Ichimura, Koichi; Fukushima, Shintaro; Totoki, Yasushi; Matsushita, Yuko; Otsuka, Ayaka; Tomiyama, Arata; Niwa, Tohru; Takami, Hirokazu; Nakamura, Taishi; Suzuki, Tomonari; Fukuoka, Kohei; Yanagisawa, Takaaki; Mishima, Kazuhiko; Nakazato, Yoichi; Hosoda, Fumie; Narita, Yoshitaka; Shibui, Soichiro; Yoshida, Akihiko; Mukasa, Akitake; Saito, Nobuhito; Kumabe, Toshihiro; Kanamori, Masayuki; Tominaga, Teiji; Kobayashi, Keiichi; Shimizu, Saki; Nagane, Motoo; Iuchi, Toshihiko; Mizoguchi, Masahiro; Yoshimoto, Koji; Tamura, Kaoru; Maehara, Taketoshi; Sugiyama, Kazuhiko; Nakada, Mitsutoshi; Sakai, Keiichi; Kanemura, Yonehiro; Nonaka, Masahiro; Asai, Akio; Yokogami, Kiyotaka; Takeshima, Hideo; Kawahara, Nobutaka; Takayama, Tatsuya; Yao, Masahiro; Kato, Mamoru; Nakamura, Hiromi; Hama, Natsuko; Sakai, Ryuichi; Ushijima, Toshikazu; Matsutani, Masao; Shibata, Tatsuhiro; Nishikawa, Ryo.
Afiliação
  • Ichimura K; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan. kichimur@ncc.go.jp.
  • Fukushima S; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
  • Totoki Y; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
  • Matsushita Y; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
  • Otsuka A; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Tomiyama A; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
  • Niwa T; Division of Refractory and Advanced Cancer, National Cancer Center Research Institute, Tokyo, Japan.
  • Takami H; Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
  • Nakamura T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
  • Suzuki T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
  • Fukuoka K; Department of Neurosurgery, Yokohama City University Faculty of Medicine, Yokohama, Japan.
  • Yanagisawa T; Department of Neuro-oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan.
  • Mishima K; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
  • Nakazato Y; Department of Neuro-oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan.
  • Hosoda F; Department of Neuro-oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan.
  • Narita Y; Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan.
  • Shibui S; Department of Neuro-oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan.
  • Yoshida A; Department of Pathology, Hidaka Hospital, Takasaki, Japan.
  • Mukasa A; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
  • Saito N; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Kumabe T; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Kanamori M; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
  • Tominaga T; Department of Neurosurgery, The University of Tokyo Graduate School and Faculty of Medicine, Tokyo, Japan.
  • Kobayashi K; Department of Neurosurgery, The University of Tokyo Graduate School and Faculty of Medicine, Tokyo, Japan.
  • Shimizu S; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Nagane M; Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Japan.
  • Iuchi T; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Mizoguchi M; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Yoshimoto K; Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan.
  • Tamura K; Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan.
  • Maehara T; Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan.
  • Sugiyama K; Department of Neurosurgery, Chiba Cancer Center, Chiba, Japan.
  • Nakada M; Department of Neurosurgery, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
  • Sakai K; Department of Neurosurgery, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
  • Kanemura Y; Department of Neurosurgery, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
  • Nonaka M; Department of Neurosurgery, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
  • Asai A; Department of Clinical Oncology and Neuro-oncology Program, Hiroshima University Hospital, Hiroshima, Japan.
  • Yokogami K; Department of Neurosurgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
  • Takeshima H; Department of Neurosurgery, Shinshu Ueda Medical Center, Ueda, Japan.
  • Kawahara N; Department of Neurosurgery and Institute for Clinical Research, Osaka National Hospital, Osaka, Japan.
  • Takayama T; Department of Neurosurgery and Institute for Clinical Research, Osaka National Hospital, Osaka, Japan.
  • Yao M; Department of Neurosurgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan.
  • Kato M; Department of Neurosurgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan.
  • Nakamura H; Department of Neurosurgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
  • Hama N; Department of Neurosurgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
  • Sakai R; Department of Neurosurgery, Yokohama City University Faculty of Medicine, Yokohama, Japan.
  • Ushijima T; Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Matsutani M; Department of Urology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
  • Shibata T; Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Nishikawa R; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Acta Neuropathol ; 131(6): 889-901, 2016 06.
Article em En | MEDLINE | ID: mdl-26956871
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Neoplasias do Sistema Nervoso Central / Neoplasias Embrionárias de Células Germinativas / Serina-Treonina Quinases TOR / Mutação Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Acta Neuropathol Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Neoplasias do Sistema Nervoso Central / Neoplasias Embrionárias de Células Germinativas / Serina-Treonina Quinases TOR / Mutação Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Acta Neuropathol Ano de publicação: 2016 Tipo de documento: Article