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Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase.
Würtz, Peter; Wang, Qin; Soininen, Pasi; Kangas, Antti J; Fatemifar, Ghazaleh; Tynkkynen, Tuulia; Tiainen, Mika; Perola, Markus; Tillin, Therese; Hughes, Alun D; Mäntyselkä, Pekka; Kähönen, Mika; Lehtimäki, Terho; Sattar, Naveed; Hingorani, Aroon D; Casas, Juan-Pablo; Salomaa, Veikko; Kivimäki, Mika; Järvelin, Marjo-Riitta; Davey Smith, George; Vanhala, Mauno; Lawlor, Debbie A; Raitakari, Olli T; Chaturvedi, Nish; Kettunen, Johannes; Ala-Korpela, Mika.
Afiliação
  • Würtz P; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland. Electronic address: peter.wurtz@computationalmedicine.fi.
  • Wang Q; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Soininen P; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Kangas AJ; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland.
  • Fatemifar G; Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Tynkkynen T; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Tiainen M; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Perola M; National Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; University of Tartu, Estonian Genome Center, Tartu, Estonia.
  • Tillin T; Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Hughes AD; Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Mäntyselkä P; Primary Health Care, School of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Kähönen M; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
  • Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Tampere, Finland.
  • Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Hingorani AD; Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Casas JP; Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Salomaa V; National Institute for Health and Welfare, Helsinki, Finland.
  • Kivimäki M; Department of Epidemiology and Public Health, University College London, London, United Kingdom; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Järvelin MR; Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Helsinki, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom; Oulu University Hospital, Oulu, Finland.
  • Davey Smith G; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
  • Vanhala M; Primary Health Care, School of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland; Primary Health Care, Central Finland Central Hospital, Jyväskylä, Finland.
  • Lawlor DA; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
  • Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
  • Chaturvedi N; Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Kettunen J; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Ala-Korpela M; Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Medical Research Council Integrative Epidemiology Unit
J Am Coll Cardiol ; 67(10): 1200-1210, 2016 Mar 15.
Article em En | MEDLINE | ID: mdl-26965542
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Inibidores de Hidroximetilglutaril-CoA Redutases / Metabolômica / Análise da Randomização Mendeliana / Previsões / Hidroximetilglutaril-CoA Redutases Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Am Coll Cardiol Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Inibidores de Hidroximetilglutaril-CoA Redutases / Metabolômica / Análise da Randomização Mendeliana / Previsões / Hidroximetilglutaril-CoA Redutases Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Am Coll Cardiol Ano de publicação: 2016 Tipo de documento: Article