Your browser doesn't support javascript.
loading
Understanding cochleate formation: insights into structural development.
Nagarsekar, Kalpa; Ashtikar, Mukul; Steiniger, Frank; Thamm, Jana; Schacher, Felix; Fahr, Alfred.
Afiliação
  • Nagarsekar K; Lehrstuhl für Pharmazeutische Technologie, Institut für Pharmazie, Friedrich-Schiller-Universität Jena, Lessingstraße 8, 07743 Jena, Germany. alfred.fahr@uni-jena.de.
  • Ashtikar M; Lehrstuhl für Pharmazeutische Technologie, Institut für Pharmazie, Friedrich-Schiller-Universität Jena, Lessingstraße 8, 07743 Jena, Germany. alfred.fahr@uni-jena.de.
  • Steiniger F; Elektronenmikroskopisches Zentrum, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07743 Jena, Germany.
  • Thamm J; Lehrstuhl für Pharmazeutische Technologie, Institut für Pharmazie, Friedrich-Schiller-Universität Jena, Lessingstraße 8, 07743 Jena, Germany. alfred.fahr@uni-jena.de.
  • Schacher F; Institut für Organische Chemie und Makromolekulare Chemie Friedrich-Schiller-Universität Jena, Lessingstraße 8, 07743 Jena, Germany and Jena Center for Soft Matter, Friedrich-Schiller-Universität Jena, Philosophenweg 7, 07743 Jena, Germany.
  • Fahr A; Lehrstuhl für Pharmazeutische Technologie, Institut für Pharmazie, Friedrich-Schiller-Universität Jena, Lessingstraße 8, 07743 Jena, Germany. alfred.fahr@uni-jena.de.
Soft Matter ; 12(16): 3797-809, 2016 Apr 20.
Article em En | MEDLINE | ID: mdl-26997365
Understanding the structure and the self-assembly process of cochleates has become increasingly necessary considering the advances of this drug delivery system towards the pharmaceutical industry. It is well known that the addition of cations like calcium to a dispersion of anionic lipids such as phosphatidylserines results in stable, multilamellar cochleates through a spontaneous assembly. In the current investigation we have studied the intermediate structures generated during this self-assembly of cochleates. To achieve this, we have varied the process temperature for altering the rate of cochleate formation. Our findings from electron microscopy studies showed the formation of ribbonlike structures, which with proceeding interaction associate to form lipid stacks, networks and eventually cochleates. We also observed that the variation in lipid acyl chains did not make a remarkable difference to the type of structure evolved during the formation of cochleates. More generally, our observations provide a new insight into the self-assembly process of cochleates based on which we have proposed a pathway for cochleate formation from phosphatidylserine and calcium. This knowledge could be employed in using cochleates for a variety of possible biomedical applications in the future.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Cálcio / Modelos Químicos Tipo de estudo: Prognostic_studies Idioma: En Revista: Soft Matter Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Cálcio / Modelos Químicos Tipo de estudo: Prognostic_studies Idioma: En Revista: Soft Matter Ano de publicação: 2016 Tipo de documento: Article