Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As).

Li, Liang; Huang, Xue-juan; Peng, Jian-long; Zheng, Ming-yue; Zhong, Da-fang; Zhang, Chao-feng; Chen, Xiao-yan

Li, Liang; Huang, Xue-juan; Peng, Jian-long; Zheng, Ming-yue; Zhong, Da-fang; Zhang, Chao-feng; Chen, Xiao-yan.

Afiliação

Li L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Huang XJ; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China.
Peng JL; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Zheng MY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Zhong DF; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Zhang CF; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China. Electronic address: njchaofeng@126.com.
Chen XY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China. Electronic address: xychen@simm.ac.cn.

Phytomedicine ; 23(4): 340-9, 2016 Apr 15.

Article em En | MEDLINE | ID: mdl-27002404

Assuntos

Cumarínicos/farmacocinética; Glucuronídeos/metabolismo; Glucuronosiltransferase/metabolismo; Mucosa Intestinal/metabolismo; Rim/metabolismo; Fígado/metabolismo; Difosfato de Uridina/metabolismo; Animais; Asteraceae/química; Disponibilidade Biológica; Cumarínicos/metabolismo; Ácido Glucurônico/metabolismo; Humanos; Masculino; Espectrometria de Massas; Metilação; Microssomos/metabolismo; Simulação de Acoplamento Molecular; Extratos Vegetais/metabolismo; Isoformas de Proteínas; Ratos; UDP-Glucuronosiltransferase 1A

Palavras-chave

Metabolism; Molecular docking; Uridine diphosphate-glucuronosyltransferase (UGT); Wedelolactone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Difosfato de Uridina / Glucuronosiltransferase / Cumarínicos / Glucuronídeos / Mucosa Intestinal / Rim / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Phytomedicine Ano de publicação: 2016 Tipo de documento: Article

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