Neuropeptide diversity and the regulation of social behavior in New World primates.
Front Neuroendocrinol
; 42: 18-39, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27020799
ABSTRACT
Oxytocin (OT) and vasopressin (AVP) are important hypothalamic neuropeptides that regulate peripheral physiology, and have emerged as important modulators of brain function, particularly in the social realm. OT structure and the genes that ultimately determine structure are highly conserved among diverse eutherian mammals, but recent discoveries have identified surprising variability in OT and peptide structure in New World monkeys (NWM), with five new OT variants identified to date. This review explores these new findings in light of comparative OT/AVP ligand evolution, documents coevolutionary changes in the oxytocin and vasopressin receptors (OTR and V1aR), and highlights the distribution of neuropeptidergic neurons and receptors in the primate brain. Finally, the behavioral consequences of OT and AVP in regulating NWM sociality are summarized, demonstrating important neuromodulatory effects of these compounds and OT ligand-specific influences in certain social domains.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Primatas
/
Comportamento Social
/
Comportamento Animal
/
Encéfalo
/
Ocitocina
/
Vasopressinas
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Receptores de Vasopressinas
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Receptores de Ocitocina
Tipo de estudo:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
Idioma:
En
Revista:
Front Neuroendocrinol
Ano de publicação:
2016
Tipo de documento:
Article