New strategies against drug resistance to herpes simplex virus.
Int J Oral Sci
; 8(1): 1-6, 2016 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-27025259
ABSTRACT
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Estomatite Herpética
/
Resistência a Medicamentos
/
Extratos Vegetais
/
Simplexvirus
/
Herpes Labial
/
Nucleosídeos
Limite:
Humans
Idioma:
En
Revista:
Int J Oral Sci
Ano de publicação:
2016
Tipo de documento:
Article