Mediator and TREX-2: Emerging links between transcription initiation and mRNA export.
Nucleus
; 7(2): 126-31, 2016 04 25.
Article
em En
| MEDLINE
| ID: mdl-27028218
ABSTRACT
Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated TREX-2 complex and promoter-bound Mediator. This highlights how nuclear-pore associated adaptors gain regulatory access to the core transcription machinery. In this Extra View, we discuss an additional implication that arises from our work and the recent literature how promoter elements may regulate mRNA metabolism beyond transcription initiation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transporte de RNA
/
Endodesoxirribonucleases
/
Iniciação da Transcrição Genética
Limite:
Humans
Idioma:
En
Revista:
Nucleus
Ano de publicação:
2016
Tipo de documento:
Article