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Unexpected Photo-instability of 2,6-Sulfonamide-Substituted BODIPYs and Its Application to Caged GABA.
Takeda, Aoi; Komatsu, Toru; Nomura, Hiroshi; Naka, Masamitsu; Matsuki, Norio; Ikegaya, Yuji; Terai, Takuya; Ueno, Tasuku; Hanaoka, Kenjiro; Nagano, Tetsuo; Urano, Yasuteru.
Afiliação
  • Takeda A; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Komatsu T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. tkomatsu@mol.f.u-tokyo.ac.jp.
  • Nomura H; PRESTO (Japan) Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama, 332-0012, Japan. tkomatsu@mol.f.u-tokyo.ac.jp.
  • Naka M; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Matsuki N; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Ikegaya Y; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Terai T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Ueno T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Hanaoka K; CREST (Japan) Agency for Medicinal Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.
  • Nagano T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  • Urano Y; CREST (Japan) Agency for Medicinal Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.
Chembiochem ; 17(13): 1233-40, 2016 07 01.
Article em En | MEDLINE | ID: mdl-27038199
ABSTRACT
Investigation of the unexpected photo-instability of 2,6-sulfonamide-substituted derivatives of the boron dipyrromethene (BODIPY) fluorophore led to the discovery of a photoreaction accompanied by multiple bond scissions. We characterized the photoproducts and utilized the photoreaction to design a caged γ-aminobutyric acid (GABA) derivative that can release GABA upon irradiation in the visible range (>450 nm). This allowed us to stimulate neural cells in mouse brain slices.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Compostos de Boro / Ácido gama-Aminobutírico Limite: Animals / Humans Idioma: En Revista: Chembiochem Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Compostos de Boro / Ácido gama-Aminobutírico Limite: Animals / Humans Idioma: En Revista: Chembiochem Ano de publicação: 2016 Tipo de documento: Article