High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences.

Bogdan, Andrew R; Charaschanya, Manwika; Dombrowski, Amanda W; Wang, Ying; Djuric, Stevan W

Bogdan, Andrew R; Charaschanya, Manwika; Dombrowski, Amanda W; Wang, Ying; Djuric, Stevan W.

Afiliação

Bogdan AR; Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Charaschanya M; Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66047, United States.
Dombrowski AW; Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Wang Y; Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Djuric SW; Discovery Chemistry and Technologies, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

Org Lett ; 18(8): 1732-5, 2016 Apr 15.

Article em En | MEDLINE | ID: mdl-27046640

ABSTRACT

ABSTRACT

A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Qualitative_research Idioma: En Revista: Org Lett Ano de publicação: 2016 Tipo de documento: Article

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