High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences.
Org Lett
; 18(8): 1732-5, 2016 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-27046640
ABSTRACT
A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Qualitative_research
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2016
Tipo de documento:
Article