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The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
Wang, Huan; Hesek, Dusan; Lee, Mijoon; Lastochkin, Elena; Oliver, Allen G; Chang, Mayland; Mobashery, Shahriar.
Afiliação
  • Wang H; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
  • Hesek D; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
  • Lee M; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
  • Lastochkin E; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
  • Oliver AG; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
  • Chang M; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
  • Mobashery S; Department of Chemistry and Biochemistry, University of Notre Dame , 423 Nieuwland Hall, Notre Dame, Indiana 46556, United States.
J Nat Prod ; 79(4): 1219-22, 2016 Apr 22.
Article em En | MEDLINE | ID: mdl-27049333
ABSTRACT
Four possible isomers of essramycin, a natural product from a marine Streptomyces species isolated from the Egyptian Mediterranean coast, were synthesized. The structures for the isomers were assigned unequivocally by (1)H NMR, (13)C NMR, high-resolution mass spectrometry, and X-ray crystal structure determinations. Notwithstanding the earlier report of broad-spectrum antibacterial activity for the natural product, none of the four isomers exhibited any such activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Streptomyces / Triazóis / Produtos Biológicos / Antibacterianos País/Região como assunto: Africa Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Streptomyces / Triazóis / Produtos Biológicos / Antibacterianos País/Região como assunto: Africa Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article