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High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.
Bate-Eya, Laurel T; den Hartog, Ilona J M; van der Ploeg, Ida; Schild, Linda; Koster, Jan; Santo, Evan E; Westerhout, Ellen M; Versteeg, Rogier; Caron, Huib N; Molenaar, Jan J; Dolman, M Emmy M.
Afiliação
  • Bate-Eya LT; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • den Hartog IJ; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • van der Ploeg I; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Schild L; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Koster J; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Santo EE; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Westerhout EM; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Versteeg R; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Caron HN; Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Molenaar JJ; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
  • Dolman ME; Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
Oncotarget ; 7(19): 27946-58, 2016 May 10.
Article em En | MEDLINE | ID: mdl-27056887
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Protocolos de Quimioterapia Combinada Antineoplásica / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 / Proteína de Sequência 1 de Leucemia de Células Mieloides / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Protocolos de Quimioterapia Combinada Antineoplásica / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 / Proteína de Sequência 1 de Leucemia de Células Mieloides / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article